Frank Staal
Professor at Leiden University Medical Center
University of Rotterdam
Netherlands
Biography
Professor Frank Staal’s research is centred around the differentiation of blood-forming stem cells (hematopoietic stem cells, HSCs) to the major disease fighting white blood cells The research of Frank J.T. Staal focuses on molecular regulation of immature T lymphocyte development and hematopoietic stem cell biology. Besides basic aspects of transcriptional regulation and cell signalling in mouse and human, this knowledge is applied to diagnosis and gene therapy applications of primary human immunodeficiencies as well as to abnormal lymphoid development in acute lymphoblastic leukemias. Translational research leading to novel diagnostic and therapeutic tools is an integral part of his research activities.
Research Interest
Retroviral transduction ,Gene therapy,Stem cell assays, FTOC, Reporter gene assays, Immunology assays, T cell clones; Molecular biological techniques, Protein chemistry, Kinase assays