Frank J.T. Staal
Leiden University Medical Center -Netherlands
Biography
Frank Staal’s research is centred around the differentiation of blood-forming stem cells (hematopoietic stem cells, HSCs) to the major disease fighting white blood cells The research of Frank J.T. Staal focuses on molecular regulation of immature T lymphocyte development and hematopoietic stem cell biology. Besides basic aspects of transcriptional regulation and cell signalling in mouse and human, this knowledge is applied to diagnosis and gene therapy applications of primary human immunodeficiencies as well as to abnormal lymphoid development in acute lymphoblastic leukemias. Translational research leading to novel diagnostic and therapeutic tools is an integral part of his research activities
Abstract
Abstract : Stem cell based gene therapy for Recombinase deficient-SCID